Dysregulated IFN-γ signals promote autoimmunity in STAT1 gain-of-function syndrome

Authors: Andrea D. Largent, Katharina Lambert, Kristy Chiang, Natali Shumlak, Denny Liggitt, Mohammed Oukka, Troy R. Torgerson, Jane H. Buckner, Eric J. Allenspach, David J. Rawlings, Shaun W. Jackson

Published: 2023-07-05

DOI: 10.1126/scitranslmed.ade7028

Source: Full article

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Abstract

Heterozygous signal transducer and activator of transcription 1 (