Authors: Su’an Tang, Lutian Yao, Jianzhao Ruan, Jingliang Kang, Yumei Cao, Xiaoyu Nie, Weiren Lan, Zhaohua Zhu, Weiyu Han, Yongguang Liu, Jing Tian, Patrick Seale, Ling Qin, Changhai Ding
Published: 2024-01-24
DOI: 10.1126/scitranslmed.adf4590
Source: Full article
The infrapatellar fat pad (IPFP) and synovium play essential roles in maintaining knee joint homeostasis and in the progression of osteoarthritis (OA). The cellular and transcriptional mechanisms regulating the function of these specialized tissues under healthy and diseased conditions are largely unknown. Here, single-cell and single-nuclei RNA sequencing of human IPFP and synovial tissues were performed to elucidate the cellular composition and transcriptional profile. Computational trajectory analysis revealed that dipeptidyl peptidase 4