Primary exposure to Zika virus is linked with increased risk of symptomatic dengue virus infection with serotypes 2, 3, and 4, but not 1

Authors: José Victor Zambrana, Chloe M. Hasund, Rosemary A. Aogo, Sandra Bos, Sonia Arguello, Karla Gonzalez, Damaris Collado, Tatiana Miranda, Guillermina Kuan, Aubree Gordon, Angel Balmaseda, Leah C. Katzelnick, Eva Harris

Published: 2024-05-29

DOI: 10.1126/scitranslmed.adn2199

Source: Full article

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Abstract

Infection with any of the four dengue virus serotypes (DENV1–4) can protect against or enhance subsequent dengue depending on preexisting antibodies and infecting serotype. Additionally, primary infection with the related flavivirus Zika virus (ZIKV) is associated with increased risk of DENV2 disease. Here, we measured how prior DENV and ZIKV immunity influenced risk of disease caused by DENV1–4 in a pediatric Nicaraguan cohort. Of 3412 participants in 2022, 10.6% experienced dengue cases caused by DENV1 (