Authors: Taoxia Liu, Fanqi Liu, Xindi Li, Suying Xu, Leyu Wang
Published: 2025-04-24
Source: Full article
AbstractExcellent multifunctional platforms for cancer diagnosis and treatment are highly desirable. Herein, multifunctional nanocomposites are constructed by utilizing Mn2+ to coordinate to the imidazole moiety anchored on CuO2 nanoparticles through cyclodextrin‐adamantane interaction. The encapsulated CuO2 nanoparticles (NPs) can generate hydrogen peroxide (H2O2) at tumor sites under acidic conditions upon decomposition, which is further turned into oxygen (O2) under Mn2+ catalysis, facilitating both ultrasound and magnetic resonance imaging (MRI). Moreover, the proposed nanomedicine enhances reactive oxygen species (ROS) generation and depletes glutathione (GSH), leading to increased lipid peroxidation (LPO) and effective ferroptosis‐mediated cancer therapy. Such a strategy presents a promising approach for the development of theranostics for imaging‐guided tumor therapy.