Abstract 13383: The Vascular Endothelial Barrier: A Novel Therapeutic Target for Preventing Atrial Fibrillation

Authors: Louisa Mezache, Heather Struckman, Anna Phillips, Stephen Baine, Amara Greer-short, Sandor Gyorke, Przemyslaw Radwanski, Thomas J Hund, Rengasayee Veeraraghavan

Published: 2021-05-10

DOI: 10.1161/circ.142.suppl_3.13383

Source: Full article


Abstract

Atrial fibrillation (AF), the most common arrhythmia, is associated with inflammation and vascular dysfunction. AF patients have elevated levels of vascular endothelial growth factor (VEGF; 90-580 pg/ml), which promotes vascular leak and edema. We have previously identified edema-induced disruption of sodium channel (Na