Authors: Hila Zak, Eyal Rozenfeld, Mali Levi, Patricia Deng, David Gorelick, Hadar Pozeilov, Shai Israel, Yoav Paas, Yoav Paas, Jin Billy Li, Moshe Parnas, Galit Shohat-Ophir
Published: 2024-09-04
Source: Full article
A-to-I RNA editing is a cellular mechanism that generates transcriptomic and proteomic diversity, which is essential for neuronal and immune functions. It involves the conversion of specific adenosines in RNA molecules to inosines, which are recognized as guanosines by cellular machinery. Despite the vast number of editing sites observed across the animal kingdom, pinpointing critical sites and understanding their in vivo functions remains challenging. Here, we study the function of an evolutionary conserved editing site in