Tumor suppressor FRMD3 controls mammary epithelial cell fate determination via notch signaling pathway

Authors: Ji Ma, Yuqing Gong, Xiaoran Sun, Cheng Liu, Xueying Li, Yi Sun, Decao Yang, Junming He, Mengyuan Wang, Juan Du, Jing Zhang, Weizhi Xu, Tianzhuo Wang, Xiaochun Chi, Yan Tang, Jiagui Song, Yunling Wang, Fei Ma, Ceshi Chen, Hongquan Zhang, Jun Zhan

Published: 2024-07-03

DOI: 10.1126/sciadv.adk8958

Source: Full article


Abstract

The luminal-to-basal transition in mammary epithelial cells (MECs) is accompanied by changes in epithelial cell lineage plasticity; however, the underlying mechanism remains elusive. Here, we report that deficiency of