In vitro selection and analysis of SARS-CoV-2 nirmatrelvir resistance mutations contributing to clinical virus resistance surveillance

Authors: Yuao Zhu, Irina Yurgelonis, Stephen Noell, Qingyi Yang, Shunjie Guan, Zhenghui Li, Li Hao, Hussin Rothan, Devendra K. Rai, Patricia McMonagle, Mary Lynn Baniecki, Samantha E. Greasley, Olga Plotnikova, Jonathan Lee, Jennifer A. Nicki, RoseAnn Ferre, Laura J. Byrnes, Wei Liu, Timothy K. Craig, Claire M. Steppan, Paul Liberator, Holly D. Soares, Charlotte M. N. Allerton, Annaliesa S. Anderson, Rhonda D. Cardin

Published: 2024-07-24

DOI: 10.1126/sciadv.adl4013

Source: Full article

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Abstract

To facilitate the detection and management of potential clinical antiviral resistance, in vitro selection of drug-resistant severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) against the virus M