Authors: Sukanya Chakravarty, Merina Varghese, Shumin Fan, Roger Travis Taylor, Ritu Chakravarti, Saurabh Chattopadhyay
Published: 2024-08-09
Source: Full article
Viral inflammation contributes to pathogenesis and mortality during respiratory virus infections. IRF3, a critical component of innate antiviral immune responses, interacts with pro-inflammatory transcription factor NF-κB, and inhibits its activity. This mechanism helps suppress inflammatory gene expression in virus-infected cells and mice. We evaluated the cells responsible for IRF3-mediated suppression of viral inflammation using newly engineered conditional