Authors: Yuanzhang Zhou, Peng Chu, Ya Wang, Na Li, Qiong Gao, Shengnan Wang, Juncheng Wei, Guoqing Xue, Yue Zhao, Huijun Jia, Jiankun Song, Yue Zhang, Yujie Pang, Houyu Zhu, Jia Sun, Suxian Ma, Chen Su, Bingjin Hu, Zhuoyue Zhao, Hui Zhang, Janice Lu, Jian Wang, Hongjiang Wang, Zhaolin Sun, Deyu Fang
Published: 2024-08-16
Source: Full article
Chronic stress–induced epinephrine (EPI) accelerates breast cancer progression and metastasis, but the molecular mechanisms remain unclear. Herein, we found a strong positive correlation between circulating EPI levels and the tumoral expression of ubiquitin-specific peptidase 22 (USP22) in patients with breast cancer. USP22 facilitated EPI-induced breast cancer progression and metastasis by enhancing adipose triglyceride lipase (ATGL)–mediated lipolysis. Targeted USP22 deletion decreased ATGL expression and lipolysis, subsequently inhibiting EPI-mediated breast cancer lung metastasis. USP22 acts as a bona fide deubiquitinase for the