LINE1 modulate human T cell function by regulating protein synthesis during the life span

Authors: Filippo V. Burattin, Rebecca Vadalà, Michele Panepuccia, Valeria Ranzani, Mariacristina Crosti, Federico A. Colombo, Cristina Ruberti, Elisa Erba, Daniele Prati, Teresa Nittoli, Giovanni Montini, Andrea Ronchi, Lorenza Pugni, Fabio Mosca, Sara Ricciardi, Sergio Abrignani, Carlo Pietrasanta, Federica Marasca, Beatrice Bodega

Published: 2024-10-09

DOI: 10.1126/sciadv.ado2134

Source: Full article

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Abstract

The molecular mechanisms responsible for the heightened reactivity of quiescent T cells in human early life remain largely elusive. Our previous research identified that quiescent adult naïve CD4