Authors: Marina Casiraghi, Haoqing Wang, Patrick C. Brennan, Chris Habrian, Harald Hübner, Maximilian F. Schmidt, Luis Maul, Biswaranjan Pani, Sherif M. F. M. Bahriz, Bing Xu, Nico Staffen, Tufa E. Assafa, Bohan Chen, Elizabeth White, Roger K. Sunahara, Asuka Inoue, Yang K. Xiang, Robert J. Lefkowitz, Ehud Y. Isacoff, Nathaniel Nucci, Peter Gmeiner, Michael T. Lerch, Brian K. Kobilka
Published: 2025-03-19
Source: Full article
G protein–coupled receptors (GPCRs) exhibit varying degrees of selectivity for different G protein isoforms. Despite the abundant structures of GPCR–G protein complexes, little is known about the mechanism of G protein coupling specificity. The β