Physiological cost of antibiotic resistance: Insights from a ribosome variant in bacteria

Authors: Eun Chae Moon, Tushar Modi, Dong-yeon D. Lee, Danis Yangaliev, Jordi Garcia-Ojalvo, S. Banu Ozkan, Gürol M. Süel

Published: 2024-11-15

DOI: 10.1126/sciadv.adq5249

Source: Full article

---

Abstract

Antibiotic-resistant ribosome variants arise spontaneously in bacterial populations; however, their impact on the overall bacterial physiology remains unclear. We studied the naturally arising antibiotic-resistant L22* ribosome variant of