Control of striatal circuit development by the chromatin regulator

Authors: Kyuhyun Choi, Nathan T. Henderson, Emily R. Feierman, Sean Louzon, Jamie Galanaugh, Felicia Davatolhagh, Isha Bhandaru, David J. Tischfield, Stewart A. Anderson, Erica Korb, Marc V. Fuccillo

Published: 2025-01-17

DOI: 10.1126/sciadv.adq6663

Source: Full article


Abstract

The pathophysiology of neurodevelopmental disorders involves vulnerable neural populations, including striatal circuitry, and convergent molecular nodes, including chromatin regulation and synapse function. Despite this, how epigenetic regulation regulates striatal development is understudied. Recurrent de novo mutations in