The Ptch/SPOUT1 methyltransferase deposits an m

Authors: Jie Chen, Yaofu Bai, Yuantai Huang, Min Cui, Yiqing Wang, Zhenqi Gu, Xiaolong Wu, Yubin Li, Yikang S. Rong

Published: 2024-12-13

DOI: 10.1126/sciadv.adr1743

Source: Full article


Abstract

The ribosomal RNA (rRNA) is one of the most heavily modified RNA species in nature. Although we have advanced knowledge of the sites, functions, and the enzymology of many of the rRNA modifications from all kingdoms of life, we lack basic understanding of many of those that are not universally present. A single N