High-affinity PQQ import is widespread in Gram-negative bacteria

Authors: Fabian Munder, Marcos Voutsinos, Klaus Hantke, Hari Venugopal, Rhys Grinter

Published: 2025-05-30

DOI: 10.1126/sciadv.adr2753

Source: Full article

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Abstract

Pyrroloquinoline quinone (PQQ) is a soluble redox cofactor used by diverse bacteria. Many Gram-negative bacteria that encode PQQ-dependent enzymes do not produce it and instead obtain it from the environment. To achieve this,