Phagocytosis-driven neurodegeneration through opposing roles of an ABC transporter in neurons and phagocytes

Authors: Xinchen Chen, Bei Wang, Ankita Sarkar, Zixian Huang, Nicolas Vergara Ruiz, Ann T. Yeung, Rachael Chen, Chun Han

Published: 2025-03-12

DOI: 10.1126/sciadv.adr5448

Source: Full article

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Abstract

Lipid homeostasis is critical to neuronal survival. ATP-binding cassette A (ABCA) proteins are lipid transporters associated with neurodegenerative diseases. How ABCA transporters regulate lipid homeostasis in neurodegeneration is an outstanding question. Here we report that the