The sodium leak channel NALCN is regulated by neuronal SNARE complex proteins

Authors: Samuel Usher, Estelle Toulmé, Roberta Florea, Stanislau Yatskevich, Christine C. Jao, Luuk R. H. Dijkhof, Janne M. Colding, Prajakta Joshi, Inna Zilberleyb, Thorsten Trimbuch, Bettina Brokowski, Alexander S. Hauser, Alexander Leitner, Christian Rosenmund, Marc Kschonsak, Stephan A. Pless

Published: 2025-03-14

DOI: 10.1126/sciadv.ads6004

Source: Full article


Abstract

NALCN (sodium leak channel, nonselective) is vital for regulating electrical activity in neurons and other excitable cells, and mutations in the channel or its auxiliary proteins lead to severe neurodevelopmental disorders. Here, we show that the neuronal SNARE (soluble