CD38-mediated metabolic reprogramming promotes the stability and suppressive function of regulatory T cells in tumor

Authors: Ishita Sarkar, Debashree Basak, Puspendu Ghosh, Anupam Gautam, Arpita Bhoumik, Praveen Singh, Anwesha Kar, Shaun Mahanti, Snehanshu Chowdhury, Lagnajita Chakraborty, Soumya Mondal, Ramanuj Mukherjee, Shikhar Mehrotra, Saikat Majumder, Shantanu Sengupta, Sandip Paul, Shilpak Chatterjee

Published: 2025-03-21

DOI: 10.1126/sciadv.adt2117

Source: Full article

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Abstract

In the tumor microenvironment (TME), regulatory T cells (T