Authors: Qiao You, Jing Wu, Chaoyong Wang, Deyan Chen, Shiji Deng, Yurong Cai, Nan Zhou, Ruining Lyu, Yajie Qian, Yi Xie, Miao He, Zhiwei Wu
Published: 2025-05-16
Source: Full article
Viral muscle soreness (VMS) is a common feature during acute viral infections, including those caused by enteroviruses, and it substantially diminishes patients’ quality of life. At present, we aim to establish the “brain-muscle” axis to explore the underlying mechanisms of VMS. We initially observed that diminished pain threshold occurred in enterovirus A71 (EV-A71)–infected C57BL/6J and AG6 mice. Subsequently, RNA sequencing data showed that lipocalin 2 (LCN2) was up-regulated during multiple viral infections, including EV-A71, Japanese encephalitis virus, vesicular stomatitis virus, and West Nile virus, which all caused VMS. As expected,