Authors: Xiaoran Ding, Xiaoteng Jia, Hongming Yuan, Daxin Pang, Hualu Zhao, Peng Sun, Fangmeng Liu, Danming Chao, Meiying Xin, Caiyun Wang, Geyu Lu, Gordon Wallace
Published: 2025-05-28
Source: Full article
Metal ions are widely adopted to potentiate oxidative damage-induced immunogenic cell death (ICD) and regulate immune pathways. However, current ion delivery platforms lack precise administration over distribution and retention time within the tumor microenvironment, leading to high systemic toxicity and suboptimal therapeutic efficacy. Here, local electrochemical immunotherapy is developed by implanting a tumor microenvironment–activated Zn//MnO