Inactivation of the PHD3-FOXO3 axis blunts the type I interferon response in microglia and ameliorates Alzheimer’s disease progression

Authors: Manuel A. Sanchez-Garcia, Nieves Lara-Ureña, Rosana March-Diaz, Clara Ortega-de San Luis, Silvia Quiñones-Cañete, Bella Mora-Romero, Juan M. Barba-Reyes, Daniel Cabello-Rivera, Carmen Romero-Molina, Antonio Heras-Garvin, Victoria Navarro, Jose Lopez-Barneo, Marisa Vizuete, Javier Vitorica, Ana M. Muñoz-Cabello, Ana B. Muñoz-Manchado, Matthew E. Cokman, Alicia E. Rosales-Nieves, Alberto Pascual

Published: 2025-05-28

DOI: 10.1126/sciadv.adu2244

Source: Full article

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Abstract

Microglia respond to Alzheimer’s disease (AD) with varied transcriptional responses. We show that oligomeric Aß (oAß) induces the expression of