Authors: David Puerta, Sara Rivera-Martín, Adrián Fragoso-Luna, Susan Strome, Sarah L Crittenden, Judith Kimble, José Pérez-Martín
Published: 2025-05-30
Source: Full article
Originally known for its function in the cell cycle, the anaphase-promoting complex/cyclosome (APC/C) also plays a crucial role in regulating differentiation and maintaining cell identity. However, the mechanisms by which APC/C mediates developmental processes are not fully understood. In this study, we show that APC/C and its activator FZR-1 regulate the chromatin regulators MES-4 and MES-3. These proteins are part of histone methylation complexes essential for maintaining germline stem cell (GSC) identity in the germ line of