Authors: Chenghao Zhu, Zihao Ye, Haining Wang, Da Ma, Zhiming Li, Chao-Jun Li, Junliang Zhang
Published: 2025-03-21
Source: Full article
An efficient synthesis of chiral tertiary alcohols through asymmetric nucleophilic addition reaction of aldehyde hydrazones to simple ketones (especially aryl/methyl ketones) has been well established. Aryl aldehydes could be used as latent benzyl carbanion equivalents via reductive polarity reversal. The key to the success of the asymmetric reaction was the combination of an achiral monophosphine ligand Ph