Authors: Marloes van den Berg, Zhonghua Shi, Wout J. Claassen, Pleuni Hooijman, Christopher T. A. Lewis, Jesper L. Andersen, Robbert J. van der Pijl, Sylvia J. P. Bogaards, Stefan Conijn, Eva L. Peters, Leon P. L. Begthel, Bas Uijterwijk, Johan Lindqvist, Paul R. Langlais, Armand R. J. Girbes, Sandra Stapel, Henk Granzier, Kenneth S. Campbell, Weikang Ma, Thomas Irving, Darren T. Hwee, James J. Hartman, Fady I. Malik, Marinus Paul, Albertus Beishuizen, Julien Ochala, Leo Heunks, Coen A. C. Ottenheijm
Published: 2024-07-31
DOI: 10.1126/scitranslmed.adg3894
Source: Full article
Patients receiving mechanical ventilation in the intensive care unit (ICU) frequently develop contractile weakness of the diaphragm. Consequently, they may experience difficulty weaning from mechanical ventilation, which increases mortality and poses a high economic burden. Because of a lack of knowledge regarding the molecular changes in the diaphragm, no treatment is currently available to improve diaphragm contractility. We compared diaphragm biopsies from ventilated ICU patients (