Authors: Simon J. Guillot, Christina Lang, Marie Simonot, Daniel Beckett, Dorothée Lulé, Luisa T. Balz, Antje Knehr, Geoffrey Stuart-Lopez, Pauline Vercruysse, Stéphane Dieterlé, Patrick Weydt, Johannes Dorst, Katharina Kandler, Jan Kassubek, Laura Wassermann, Caroline Rouaux, Sébastien Arthaud, Sandrine Da Cruz, Pierre-Hervé Luppi, Francesco Roselli, Albert C. Ludolph, Luc Dupuis, Matei Bolborea
Published: 2025-01-29
DOI: 10.1126/scitranslmed.adm7580
Source: Full article
Sleep alterations have been described in several neurodegenerative diseases yet are currently poorly characterized in amyotrophic lateral sclerosis (ALS). This study investigates sleep macroarchitecture and related hypothalamic signaling disruptions in ALS. Using polysomnography, we found that both patients with ALS as well as asymptomatic