Interferon regulatory factor-1–expressing astrocytes are epigenetically controlled and exacerbate TBI-associated pathology in mice

Authors: Wenxing Cui, Hao Bai, Chengxuan Guo, Jinpeng Zhou, Dayun Feng, Shiji Zhang, Fei Gao, Liying Han, Yang Tian, Jingyu Dong, Feilong Wei, Jian Bai, Xun Wu, Yingwu Shi, Hao Guo, Liang Wang, Zhihong Li, Wei Guo, Tianzhi Zhao, Lijun Heng, Qing Cai, Haixiao Liu, Shunnan Ge, Yan Qu

Published: 2025-05-28

DOI: 10.1126/scitranslmed.adr5300

Source: Full article

---

Abstract

Astrocyte heterogeneity is closely associated with the pathophysiology of traumatic brain injury (TBI), particularly in the development of cerebral edema, which is a major contributor to morbidity and mortality in patients with TBI. However, little is known about how certain astrocyte subpopulations contribute to the development of cerebral edema after acute brain injury. Using multiomics approaches, we identified a proinflammatory interferon regulatory factor-1–positive (IRF1