A first-in-class inhibitor of homologous recombination DNA repair counteracts tumour growth, metastasis and therapeutic resistance in pancreatic cancer

Authors: Juliana Calheiros, Rita Silva, Filipa Barbosa, João Morais, Sara Reis Moura, Sofia Almeida, Elena Fiorini, Silva Mulhovo, Tatiana Q. Aguiar, Tao Wang, Sara Ricardo, Maria Inês Almeida, Lucília Domingues, Sonia A. Melo, Vincenzo Corbo, Maria-José U. Ferreira, Lucília Saraiva

Published: 2025-04-24

DOI: 10.1186/s13046-025-03389-5

Source: Full article

A first-in-class inhibitor of homologous recombination DNA repair counteracts tumour growth, metastasis and therapeutic resistance in pancreatic cancer

Abstract