Authors: Diederik L H Koelman, Matthijs C Brouwer, Diederik van de Beek
Published: 2019-07-04
DOI: 10.1093/brain/awz222
Source: Full article
Morbidity and mortality in bacterial meningitis are driven by an uncontrolled host inflammatory response. Koelman et al. evaluate the detrimental role of the complement system in spurring this inflammation, and conclude that anaphylatoxin C5a is a promising treatment target in bacterial meningitis.