Authors: Tymoteusz Zera, Davi J. A. Moraes, Melina P. da Silva, James P. Fisher, Julian F. R. Paton
Published: 2019-06-05
DOI: 10.1152/physiol.00057.2018
Source: Full article
The carotid body has emerged as a therapeutic target for cardio-respiratory-metabolic diseases. With the expansive functions of the chemoreflex, we sought mechanisms to explain differential control of individual responses. We purport a remarkable correlation between phenotype of a chemosensory unit (glomus cell-sensory afferent) with a distinct component of the reflex response. This logic could permit differential modulation of distinct chemoreflex responses, a strategy ideal for therapeutic exploitation.