Authors: Jing Guo, Adam M. Brickman, Jennifer J. Manly, Christiane Reitz, Nicole Schupf, Richard P. Mayeux, Yian Gu
Published: 2021-05-03
DOI: 10.1002/alz.12359
Source: Full article
AbstractIntroductionThere is limited and inconsistent reporting on the association between Life's Simple 7 (LS7) and dementia in the elderly population.MethodsBased on the Washington Heights‐Inwood Columbia Aging Project (WHICAP), LS7 scores were estimated to assess cardiovascular health status. Associations between LS7 scores and incident dementia were investigated by Cox proportional hazards models.ResultsAmong 1987 subjects, 291 incident cases of dementia were identified over a median follow‐up of 5.84 years. Compared with subjects in the poor cardiovascular health group (scores 0 to 5), those in intermediate (6 to 9) and optimal (10 to 14) groups had lower dementia risk, with the hazard ratio (HR; 95% confidence interval) being 0.74 (0.54 to 1.00) and 0.59 (0.38 to 0.91), respectively. These results were significant in apolipoprotein E genotype ε4 (APOE ε4) allele non‐carriers but not in carriers.DiscussionHigher LS7 scores are protective for dementia, especially among the APOE ε4 noncarriers.